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Membrane proteins are essential for numerous cellular functions such as signal transduction, material transport, and intercellular communication. They are also one of the most targeted classes in drug development, with about two-thirds of therapeutic molecules interacting with them. Despite their importance, only 0.1% of membrane protein structures have been determined so far, even though they make up 20-30% of the cellular proteome.
One major challenge in studying membrane proteins is the difficulty in extracting sufficient quantities for crystallization. Traditional methods like subcellular fractionation, Triton X-114 detergent extraction, and high salt or pH buffers are often time-consuming, labor-intensive, and require expensive equipment such as ultracentrifuges.
To address this issue, Thermo Fisher Scientific’s Pierce brand introduced the Mem-PER Plus kit. It improves upon the earlier Mem-PER kit by offering a simpler and more efficient way to enrich intrinsic and membrane-associated proteins. This new generation kit uses a mild detergent to selectively extract membrane proteins, avoiding the need for hydrophobic phase separation. As a result, it provides better reproducibility and higher throughput.
The process takes less than an hour and only requires basic lab equipment like a bench-top centrifuge, homogenizer, and pipettes. It works well for both mammalian cells and various tissue types. Reports indicate that membrane proteins with one or two transmembrane domains can be extracted with up to 90% efficiency, while intracellular contamination remains below 10%.
In addition to membrane protein extraction, the platform also supports other laboratory techniques such as ELISA, Western blot (WB), immunohistochemistry, and more. Various kits are available, including SOD, IgG, IgM, and others, along with free testing options and reagent suppliers like GIBCO and AMRESCO. Shanghai Xinfan Biological offers comprehensive support for experimental procedures and research needs.
Industrial PC
Industrial PC, specifically designed for harsh industrial environments, possess many notable features. Industrial PCs have excellent stability and can operate stably for a long time under harsh conditions such as high temperature, humidity, and dust, ensuring that the production process is not disturbed. Its strong anti-interference ability is another highlight, which can effectively resist electromagnetic interference and power fluctuations, ensuring the accuracy and reliability of data transmission. Industrial computers also have a high degree of durability, with a sturdy casing and protective design that can withstand impact and vibration. In terms of performance, it has efficient computing power and fast data processing speed, which can easily cope with complex industrial control and monitoring tasks. For example, in automated production lines, industrial computers monitor the real-time operation status of equipment, timely detect and solve problems; In the intelligent warehousing system, precise management of goods in and out of storage improves logistics efficiency.
The application fields of
Industrial All-In-One PC are very extensive. In the manufacturing industry, it is the core control equipment of automated production lines, accurately controlling various machines, improving production efficiency and product quality. In the field of intelligent warehousing and logistics, it is possible to achieve rapid sorting of goods, inventory management, and real-time tracking of logistics information. In the medical industry, industrial all-in-one pcs are used for the control and data acquisition of medical equipment, such as medical imaging equipment, ward monitoring systems, etc. In the field of energy, it plays an important role in power monitoring, petrochemical production, and other aspects to ensure the safety and stability of energy production. In addition, the signal control and intelligent transportation management of rail transit in the transportation industry also rely on industrial integrated machines. For example, in automobile manufacturing factories, industrial all-in-one machines help achieve the automation process of automobile assembly; In large hospitals, all-in-one pcs ensure the stable operation of medical equipment and accurate recording of data.
Industrial Panel PC play a crucial role in numerous extreme environmental scenarios due to their wide temperature characteristics. In the cold northern factory workshop, even if the temperature is extremely low, it can still operate stably, used for monitoring and operating production equipment, real-time display of equipment operating parameters, and convenient for workers to adjust and maintain in a timely manner. In the hot desert areas of the power industry, wide temperature protection ensures its normal operation under high temperatures, used for remote monitoring and scheduling of substations, to ensure the stable operation of the power system. In mine operations with large temperature differences, it can also adapt and provide safety monitoring data and communication support for workers. For example, in extremely cold cold storage, industrial panel computers can accurately control temperature and inventory management; Real time monitoring of production processes in high-temperature steel plants.
In intelligent security monitoring systems,
Fanless Panel PC play a crucial role, demonstrating excellent adaptability and reliability. Firstly, in the monitoring center, fanless industrial computers can undertake centralized processing and analysis tasks for a large amount of video data collected by surveillance cameras. Its powerful computing power can quickly identify and filter out abnormal behavior, suspicious individuals or vehicles, and issue alerts in a timely manner. Due to the absence of noise generated by fan operation, it will not interfere with the working environment of monitoring personnel, allowing them to focus more on handling emergency situations. Secondly, in outdoor monitoring equipment, the fanless design effectively prevents foreign objects such as dust and insects from entering the computer interior, reducing the risk of equipment failure. Whether in hot summers, cold winters, or even harsh weather conditions, fanless industrial computers can operate stably, ensuring uninterrupted transmission and storage of monitoring data. Furthermore, in scenarios such as border security and important facility protection, fanless industrial pcs can work in conjunction with intelligent recognition software and sensors. For example, in border areas, it is possible to accurately identify illegal cross-border activities; Real time monitoring of unauthorized access around important facilities. For example, in the security monitoring system of a large commercial park, fanless industrial panel pc can not only process high-definition video streams from hundreds of cameras 24 hours a day without interruption, but also automatically distinguish between normal personnel activities and potential security threats, such as abnormal intrusion or abnormal stay at night, through intelligent analysis algorithms. In some remote monitoring stations, their fanless and low-power characteristics enable equipment to operate reliably even under unstable power supply conditions such as solar or wind energy.
In the field of intelligent transportation,
Embedded Computer are installed in road monitoring equipment. For example, at toll stations on highways, computers are embedded in control boxes to process vehicle information in real-time, achieving rapid toll collection and traffic management. In terms of medical equipment, such as large X-ray machines and industrial computers embedded in the body, precise control of radiation emission and image acquisition and processing provides accurate diagnostic basis for doctors. On industrial automation production lines, embedded industrial computers are installed in the control unit of the robotic arm to accurately command actions, ensuring efficient and high-quality production of products. In addition, industrial computers are embedded in the intelligent distribution cabinets of the power system to monitor power parameters in real time and ensure the safe and stable operation of the power grid.
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Shenzhen Hengstar Technology Co., Ltd. , https://www.angeltondal.com